Hpse Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comHpse Polyclonal Antibody for Mouse(Mus musculus)

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Hpse (Gene name),

Heparanase (Protein name ), HPSE_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Hpse(Hpa);

Protein name:

Heparanase;

Alternative:

Endo-glucoronidase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1.

Function:

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Highly selective enzyme cleaving HSPGs at specific intrachain sites. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Subcellular Location:

Lysosome membrane Peripheral membrane protein Secreted Nucleus Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts.

Protein Attributes:

Sequence length:

535

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

535:

PALTEKPLPA | GSALSLPAFS | YGFFVIRNAK | IAACI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q6YGZ1

KEGG:

mmu:15442

UniGene:

Mm.265786

Pfam:

PF03662

Uniprot:

Q6YGZ1

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ELISA Kit for Mouse Heparanase

Cat.:

E0711r

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Packing:

96T

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ELISA Kit for Mouse Heparanase

Cat.:

E0711h

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96T

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ELISA Kit for Mouse Heparanase

Cat.:

E0711m

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ELISA Kit for Mouse Heparanase

Cat.:

E0711b

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96T

ELISA Kit for Mouse Heparanase

Cat.:

E0711c

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96T

CLIA Kit for Mouse Heparanase

Cat.:

U0711m

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96T

CLIA Kit for Mouse Heparanase

Cat.:

U0711h

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96T

CLIA Kit for Mouse Heparanase

Cat.:

U0711b

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96T

CLIA Kit for Mouse Heparanase

Cat.:

U0711c

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96T

CLIA Kit for Mouse Heparanase

Cat.:

U0711r

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96T

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Polyclonal Antibody for Mouse Heparanase

Cat.:

P0711Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Heparanase

Cat.:

P0711Rb-m

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Polyclonal Antibody for Mouse Heparanase

Cat.:

P0711Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse Heparanase

Protein for Mouse Heparanase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis."
Hulett M.D. , Freeman C. , Hamdorf B.J. , Baker R.T. , Harris M.J. , Parish C.R.
Nat. Med.5:803-809(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: SJL/J.
tissue: Spleen.
2.

"Cloning, expression, and purification of mouse heparanase."
Miao H.-Q. , Navarro E. , Patel S. , Sargent D. , Koo H. , Wan H. , Plata A. , Zhou Q. , Ludwig D. , Bohlen P. , Kussie P.
Protein Expr. Purif.26:425-431(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 28-57 AND 150-179;GLYCOSYLATION;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBUNIT
strain: FVB.
tissue: Embryo.
3.

"Processing of macromolecular heparin by heparanase."
Gong F. , Jemth P. , Galvis M.L.E. , Vlodavsky I. , Horner A. , Lindahl U. , Li J.-P.
J. Biol. Chem.278:35152-35158(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ENZYME REGULATION
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Thymus.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
6.

"Heparanase regulates murine hair growth."
Zcharia E. , Philp D. , Edovitsky E. , Aingorn H. , Metzger S. , Kleinman H.K. , Vlodavsky I. , Elkin M.
Am. J. Pathol.166:999-1008(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models."
Zcharia E. , Zilka R. , Yaar A. , Yacoby-Zeevi O. , Zetser A. , Metzger S. , Sarid R. , Naggi A. , Casu B. , Ilan N. , Vlodavsky I. , Abramovitch R.
FASEB J.19:211-221(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYMATIC ACTIVITY;DEVELOPMENTAL STAGE
8.

"Heparanase induces Akt phosphorylation via a lipid raft receptor."
Ben-Zaken O. , Gingis-Velitski S. , Vlodavsky I. , Ilan N.
Biochem. Biophys. Res. Commun.361:829-834(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation."
Brown A.J. , Alicknavitch M. , D'Souza S.S. , Daikoku T. , Kirn-Safran C.B. , Marchetti D. , Carson D.D. , Farach-Carson M.C.
Bone43:689-699(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYMATIC ACTIVITY;PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY

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